Autoantibodies to neurotransmitter receptors and ion channels: from neuromuscular to neuropsychiatric disorders

نویسندگان

  • Pilar Martinez-Martinez
  • Peter C. Molenaar
  • Mario Losen
  • Jo Stevens
  • Marc H. De Baets
  • Andrei Szoke
  • Jerome Honnorat
  • Ryad Tamouza
  • Marion Leboyer
  • Jim Van Os
  • Bart P. F. Rutten
چکیده

Changes of voltage-gated ion channels and ligand-gated receptor channels caused by mutation or autoimmune attack are the cause of so-called channelopathies in the central and peripheral nervous system. We present the pathophysiology of channelopathies of the neuromuscular junction in terms of loss-of-function and gain-of-function principles. Autoantibodies generally have reduced access to the central nervous system, but in some cases this is enough to cause disease. A review is provided of recent findings implicating autoantibodies against ligand-activated receptor channels and potassium channels in psychiatric and neurological disorders, including schizophrenia and limbic encephalitis. The emergence of channelopathy-related neuropsychiatric disorders has implications for research and practice.

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عنوان ژورنال:

دوره 4  شماره 

صفحات  -

تاریخ انتشار 2013